The Technology

Protein-structured activators (such as oscilin) are released from the sperm cell, entering the oocyte and providing calcium oscillation. It also activates the oocyte and forms the pronucleus, evidence of fertilization. Sperm injection (ICSI) into the oocyte has significantly contributed to treating male factor-induced infertility. However, in some cases, even ICSI cannot provide fertilization. Sperm cells with morphological abnormalities or immature forms also further contribute to this fertilization failure. Research has revealed that the fertilization problem in these cases may be caused by insufficient release of the said factors from the sperm cell due to inadequate calcium stimulation (Swann K, 1996).

The electromagnetic field created by applying electric current increases the number of pores and calcium conductivity in the cell membrane by enabling the movement of proteins. This situation increases the calcium concentration in the cell (Mansour R, 2009). This high concentration of calcium triggers oocyte fertilization. Fertilization and pregnancies have been reported primarily in cases of unspecified fertilization failure cases or in cases with spermatogenic disorders (structural disorders such as globozoospermia) (Egashira A., 2009; Baltaci V., 2014; Baltaci V., 2010; Tanaka A ., 20018, Zhang J., 1999). In another critical study, it was reported that pregnancies were achieved by Round Spermatid Intracytoplasmic Injection (ROSI) following treatment of the oocyte with piezoelectric stimulation (Tanaka A., 2015).

Piezoelectric applications are becoming more and more common in infertility treatments. It is essential to eliminate fertilization problems caused by different reasons, especially male factors.

Reproductive biotechnology is where new and innovative methods are introduced and developed rapidly. ZEUS Bioscience is determined to bring new developments and produce services in line with scientific and ethical principles in this field.